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Guanfacine Hcl Coupon

Lowest discount price for: Guanfacine Hcl 1 MG TABLET at KROGER PHARMACY See More Pricing

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Coupon Price:$11.78

Guanfacine Hcl Prescription Drug Coupon

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Guanfacine Hcl 1 MG TABLET

Drug Information: Guanfacine Hcl

Indications and Usage

Guanfacine tablets, USP are indicated in the management of hypertension. Guanfacine may be given alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.

Dosing and Administration

The recommended initial dose of guanfacine tablets, USP when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. If after 3 to 4 weeks of therapy, 1 mg does not give a satisfactory result, a dose of 2 mg may be given, although most of the effect of guanfacine is seen at 1 mg. Higher daily doses have been used, but adverse reactions increase significantly with doses above 3 mg/day.

The frequency of rebound hypertension is low, but it can occur. When rebound occurs, it does so after 2 to 4 days, which is delayed compared with clonidine hydrochloride. This is consistent with the longer half-life of guanfacine. In most cases, after abrupt withdrawal of guanfacine, blood pressure returns to pretreatment levels slowly (within 2 to 4 days) without ill effects.

Dosage Forms and Strengths

  • 1 mg tablet

Contraindications

Guanfacine tablets, USP are contraindicated in patients with known hypersensitivity to guanfacine hydrochloride, USP.

Warnings and Precautions

Like other antihypertensive agents, guanfacine hydrochloride should be used with caution in patients with severe coronary insufficiency, recent myocardial infarction, cerebrovascular disease, or chronic renal or hepatic failure.

Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.

Adverse Reactions

An open-label postmarketing study involving 21,718 patients was conducted to assess the safety of guanfacine hydrochloride 1 mg/day given at bedtime for 28 days. Guanfacine was administered with or without other antihypertensive agents. Adverse events reported in the postmarketing study at an incidence greater than 1% included dry mouth, dizziness, somnolence, fatigue, headache and nausea. The most commonly reported adverse events in this study were the same as those observed in controlled clinical trials.

Less frequent, possibly guanfacine-related events observed in the postmarketing study and/or reported spontaneously include:

  • Body as a Whole: asthenia, chest pain, edema, malaise, tremor
  • Cardiovascular: bradycardia, palpitations, syncope, tachycardia
  • Central Nervous System: paresthesias, vertigo
  • Eye Disorders: blurred vision
  • Gastrointestinal System: abdominal pain, constipation, diarrhea, dyspepsia
  • Liver and Biliary System: abnormal liver function tests
  • Musculo-Skeletal System: arthralgia, leg cramps, leg pain, myalgia
  • Psychiatric: agitation, anxiety, confusion, depression, insomnia, nervousness
  • Reproductive System, Male: impotence
  • Respiratory System: dyspnea
  • Skin and Appendages: alopecia, dermatitis, exfoliative dermatitis, pruritus, rash
  • Special Senses: alterations in taste
  • Urinary System: nocturia, urinary frequency

Drug Interactions

The potential for increased sedation when guanfacine is given with other CNS-depressant drugs should be appreciated.

The administration of guanfacine concomitantly with a known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration. In such cases, therefore, more frequent dosing may be required to achieve or maintain the desired hypotensive response. Further, if guanfacine is to be discontinued in such patients, careful tapering of the dosage may be necessary in order to avoid rebound phenomena.